Journal article : Review
Guidelines on models of diabetic heart disease
- Abstract:
- Diabetes is a major risk factor for cardiovascular diseases, including diabetic cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular disease represents the number one cause of death in people with diabetes, there has been a major emphasis on understanding the mechanisms by which diabetes promotes cardiovascular disease, and how antidiabetic therapies impact diabetic heart disease. With a wide array of models to study diabetes (both type 1 and type 2), the field has made major progress in answering these questions. However, each model has its own inherent limitations. Therefore, the purpose of this guidelines document is to provide the field with information on which aspects of cardiovascular disease in the human diabetic population are most accurately reproduced by the available models. This review aims to emphasize the advantages and disadvantages of each model, and to highlight the practical challenges and technical considerations involved. We will review the preclinical animal models of diabetes (based on their method of induction), appraise models of diabetes-related atherosclerosis and heart failure, and discuss in vitro models of diabetic heart disease. These guidelines will allow researchers to select the appropriate model of diabetic heart disease, depending on the specific research question being addressed.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 2.9MB, Terms of use)
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- Publisher copy:
- 10.1152/ajpheart.00058.2022
Authors
+ Hartstichting
More from this funder
- Funder identifier:
- https://ror.org/05nxhgm70
- Grant:
- 2019T041
- Programme:
- Dekker Senior Scientist Grant
+ British Heart Foundation
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- Funder identifier:
- https://ror.org/02wdwnk04
- Grant:
- FS/17/58/33072
+ Fonds de Recherche du Québec - Santé
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- Funder identifier:
- https://ror.org/02eqrsj93
- Grant:
- 281577
+ Canadian Institutes of Health Research
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- Funder identifier:
- https://ror.org/01gavpb45
- Grant:
- PJT-156136
- PJT159648
+ Health Research Council of New Zealand
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- Funder identifier:
- https://ror.org/00zbf3d93
- Grant:
- 19/190
- Publisher:
- American Physiological Society
- Journal:
- American Journal of Physiology - Heart and Circulatory Physiology More from this journal
- Volume:
- 323
- Issue:
- 1
- Pages:
- H176-H200
- Place of publication:
- United States
- Publication date:
- 2022-06-03
- Acceptance date:
- 2022-05-27
- DOI:
- EISSN:
-
1522-1539
- ISSN:
-
0363-6135
- Pmid:
-
35657616
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1262957
- Local pid:
-
pubs:1262957
- Deposit date:
-
2025-06-11
- ARK identifier:
Terms of use
- Copyright holder:
- Heather et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Licensed under Creative Commons Attribution CC-BY 4.0.
- Licence:
- CC Attribution (CC BY)
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