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Activity-dependent exocytosis of lysosomes regulates structural plasticity of dendritic spines

Abstract:

Lysosomes have traditionally been viewed as degradative organelles, though a growing body of evidence suggests that they can function as Ca2+ stores. Here, we examined the function of these stores in hippocampal pyramidal neurons. We found that back-propagating action potentials (bpAPs) could elicit Ca2+ release from lysosomes in the dendrites. This Ca2+ release triggered the fusion of lysosomes with the plasma membrane, resulting in the release of Cathepsin B. Cathepsin B increased the activ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.neuron.2016.11.013

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Department:
Oxford, MSD, Pharmacology
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Department:
Oxford, MSD, Pharmacology
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Department:
Oxford, MSD, Pharmacology
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Department:
Oxford, MSD, Pharmacology
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Funding agency for:
Padamsey, Z
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Funding agency for:
Reinhart, M
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Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Neuron Journal website
Volume:
93
Issue:
1
Pages:
132-146
Publication date:
2016-12-15
Acceptance date:
2016-10-31
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Pubs id:
pubs:656807
URN:
uri:7344eeab-df14-4b54-808a-ba1c69a540bf
UUID:
uuid:7344eeab-df14-4b54-808a-ba1c69a540bf
Local pid:
pubs:656807
Keywords:

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