Journal article
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk
- Abstract:
- It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls). We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 795.9KB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-020-17673-9
Authors
Contributors
+ Hunter, DJ
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Role:
- Contributor
+ PRACTICAL consortium
- Role:
- Contributor
+ CRUK Consortium
- Role:
- Contributor
+ BPC3 Consortium
- Role:
- Contributor
+ CAPS Consortium
- Role:
- Contributor
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 11
- Issue:
- 1
- Article number:
- 3905
- Publication date:
- 2020-08-06
- Acceptance date:
- 2020-06-28
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
32764609
- Language:
-
English
- Keywords:
- Pubs id:
-
1125463
- Local pid:
-
pubs:1125463
- Deposit date:
-
2021-07-06
Terms of use
- Copyright holder:
- Wu et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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