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Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.

Abstract:

PURPOSE: Exudative AMD (wet AMD) is treated by monthly injection into the eye of anti-VEGF proteins. VEGF is alternatively spliced to produce numerous isoforms that differ in angiogenic activity. Serine-rich protein kinase-1 (SRPK1) has been identified as a regulator of pro-angiogenic VEGF splicing by phosphorylating serine-rich splicing factor-1 (SRSF1), which binds to VEGF pre-mRNA. We tested the hypothesis that topical (eye drop) SRPK1-selective inhibitors could be generated that reduce pr...

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Publication status:
Published

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Publisher copy:
10.1167/iovs.13-12422

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Journal:
Investigative ophthalmology and visual science
Volume:
54
Issue:
9
Pages:
6052-6062
Publication date:
2013-09-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:7316a35a-ae4b-4580-b702-447a1f74e0ee
Source identifiers:
429171
Local pid:
pubs:429171

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