- Abstract:
-
PURPOSE: Exudative AMD (wet AMD) is treated by monthly injection into the eye of anti-VEGF proteins. VEGF is alternatively spliced to produce numerous isoforms that differ in angiogenic activity. Serine-rich protein kinase-1 (SRPK1) has been identified as a regulator of pro-angiogenic VEGF splicing by phosphorylating serine-rich splicing factor-1 (SRSF1), which binds to VEGF pre-mRNA. We tested the hypothesis that topical (eye drop) SRPK1-selective inhibitors could be generated that reduce pr...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1167/iovs.13-12422
-
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- Journal:
- Investigative ophthalmology and visual science
- Volume:
- 54
- Issue:
- 9
- Pages:
- 6052-6062
- Publication date:
- 2013-09-05
- DOI:
- EISSN:
-
1552-5783
- ISSN:
-
0146-0404
- URN:
-
uuid:7316a35a-ae4b-4580-b702-447a1f74e0ee
- Source identifiers:
-
429171
- Local pid:
- pubs:429171
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.
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