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Journal article

Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry

Abstract:

Background The enantiomers of the 8-aminoquinoline anti-malarial primaquine have different pharmacological properties. Development of an analytical method for simultaneous quantification of the enantiomers of primaquine and its metabolite, carboxyprimaquine, will support clinical pharmacometric assessments. Methods A simple and sensitive method consisting of liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) was developed for simultaneous and enantiospecific determination...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-022-04191-w

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-2856-8218
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-2309-1171
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-1897-1978
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-4566-4030
Publisher:
BioMed Central
Journal:
Malaria Journal More from this journal
Volume:
21
Article number:
169
Publication date:
2022-06-03
Acceptance date:
2022-05-19
DOI:
EISSN:
1475-2875
Pmid:
35659684
Language:
English
Keywords:
Pubs id:
1263018
Local pid:
pubs:1263018
Deposit date:
2022-11-08

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