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Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study.

Abstract:

BACKGROUND: Genetic factors have a role in the pathogenesis of ischaemic stroke, but the main genes involved have yet to be defined. Mitochondrial mechanisms have been implicated in the pathophysiology of acute stroke, but the role of mitochondrial DNA (mtDNA) has not been comprehensively studied. We investigated whether there is an association between mtDNA haplotypes and incidence of stroke. METHODS: The major European mtDNA haplogroups were identified in two independent subpopulations (n=9...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Role:
Author
Journal:
The Lancet. Neurology
Volume:
9
Issue:
5
Pages:
498-503
Publication date:
2010-05-05
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
URN:
uuid:72e876fe-a0ce-4477-bf4d-d59759963146
Source identifiers:
119860
Local pid:
pubs:119860

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