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Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines

Abstract:

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further fu...

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Publication status:
Published

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Publisher copy:
10.1016/j.tet.2009.07.076

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Basutto, JA More by this author
Fishlock, LP More by this author
Procopiou, PA More by this author
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Journal:
TETRAHEDRON
Volume:
65
Issue:
44
Pages:
8969-8980
Publication date:
2009-10-31
DOI:
ISSN:
0040-4020
URN:
uuid:72d73f73-db83-4462-b3e4-1488f928be01
Source identifiers:
41449
Local pid:
pubs:41449

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