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Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

Abstract:

Background: Mammalian oocyte activation occurs via a series of intracellular calcium (Ca 2) oscillations thought to be induced by a sperm-specific phospholipase C zeta (PLCζ). There is now strong evidence to indicate that certain types of human male infertility are caused by failure of the sperm to activate the oocyte in an appropriate manner. Molecular analysis of the PLCζ gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine ...

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Publisher copy:
10.1093/humrep/der336

Authors


Rietdorf, K More by this author
Nikiforaki, D More by this author
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Journal:
Human Reproduction
Volume:
26
Issue:
12
Pages:
3372-3387
Publication date:
2011-12-05
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
URN:
uuid:72b358e1-9e09-4517-bc5d-660897059fd2
Source identifiers:
206440
Local pid:
pubs:206440

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