Journal article
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes
- Abstract:
-
Background: Mammalian oocyte activation occurs via a series of intracellular calcium (Ca 2) oscillations thought to be induced by a sperm-specific phospholipase C zeta (PLCζ). There is now strong evidence to indicate that certain types of human male infertility are caused by failure of the sperm to activate the oocyte in an appropriate manner. Molecular analysis of the PLCζ gene of a male patient with oocyte activation deficiency has previously identified a point mutation causing a histidine ...
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- Publisher copy:
- 10.1093/humrep/der336
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Bibliographic Details
- Journal:
- Human Reproduction
- Volume:
- 26
- Issue:
- 12
- Pages:
- 3372-3387
- Publication date:
- 2011-12-05
- DOI:
- EISSN:
-
1460-2350
- ISSN:
-
0268-1161
- URN:
-
uuid:72b358e1-9e09-4517-bc5d-660897059fd2
- Source identifiers:
-
206440
- Local pid:
- pubs:206440
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2011
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