Modeling alveolar volume changes during periodic breathing in heterogeneously ventilated lungs.
A simplified model of periodic breathing, proposed by Whiteley et al. (Math. Med. Biol. 20:205-224, 2003), describes a non-uniform breathing pattern for a lung with an inhomogeneous gas distribution, such as that observed in some subjects suffering from respiratory disease. This model assumes a constant alveolar volume, and predicts incidence of irregular breathing caused by small, poorly ventilated regions of the lung. Presented here is an extension to this work which, by allowing variable l...Expand abstract
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