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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus.

Abstract:

BACKGROUND: Evc is essential for Indian Hedgehog (Hh) signalling in the cartilage growth plate. The gene encoding Evc2 is in close proximity in divergent orientation to Evc and mutations in both human genes lead to the chondrodysplasia Ellis-van Creveld syndrome. RESULTS: Bioinformatic analysis reveals that the Evc and Evc2 genes arose through a duplication event early in metazoan evolution and were subsequently lost in arthropods and nematodes. Here we demonstrate that Evc2 is essential for...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/1741-7007-9-14

Authors


Tompson, S More by this author
Campbell, J More by this author
MacArthur, K More by this author
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Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Biology Journal website
Volume:
9
Issue:
1
Pages:
Article: 14
Publication date:
2011
DOI:
EISSN:
1741-7007
ISSN:
1741-7007
URN:
uuid:72914e64-9804-40c4-a373-a6477c961685
Source identifiers:
239484
Local pid:
pubs:239484

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