Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences.

Journal article

Twenty-one genes encoding surface proteins belonging to the LPXTG family have been identified by in silico analysis of six Staphylococcus aureus genome sequences. Eleven genes encode previously described proteins, while 10 have not yet been characterized. Of these, eight contain the cell-wall sorting signal LPXTG responsible for covalently anchoring proteins to the cell-wall peptidoglycan. The remaining two, SasF and SasD, harbour a single residue variation in the fourth position of the LPXTG...

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Authors: Roche, F; Massey, R; Peacock, S; Day, N; Visai, L

• Publication status: Published
• Journal: Microbiology (Reading, England)
• Volume: 149
• Issue: Pt 3
• Pages: 643-654
• Publication date: 2003-03-01
• DOI: 10.1099/mic.0.25996-0
• EISSN: 1465-2080
• ISSN: 1350-0872
• Language: English
• Keywords: Amino Acid Sequence; Humans; Membrane Proteins; Staphylococcal Infections; Molecular Sequence Data; Carrier State; Recombinant Proteins; Middle Aged; Aged; Immunoglobulin G; Amino Acid Motifs; Aged, 80 and over; Bacterial Proteins; Sequence Analysis, DNA; Antibodies, Bacterial; Polymerase Chain Reaction; Adult; Genome, Bacterial; Staphylococcus aureus