Journal article
Copper(I)-catalyzed sulfonylative Suzuki-Miyaura cross-coupling
- Abstract:
- Using a simple copper(I) catalyst has allowed a high yielding sulfonylative-Suzuki-Miyaura cross-coupling to be developed. The process provides a single step route to diaryl sulfones from the direct combination of aryl boronic acids, sulfur dioxide and aryl iodides, and represents the first sulfonylative variant of a classic cross-coupling reaction. Sulfur dioxide is delivered from the surrogate reagent, DABSO. Variation of the reaction conditions allowed interruption of the sulfonylative-Suzuki coupling, resulting in formation of a presumed Cu-sulfinate intermediate. These sufinates could be trapped with electrophiles to access to arylalkyl sulfones, β-hydroxyl sulfones, sulfonamides and sulfonyl fluorides.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1039/c6sc05483h
Authors
- Publisher:
- Royal Society of Chemistry
- Journal:
- Chemical Science More from this journal
- Volume:
- 8
- Issue:
- 4
- Pages:
- 3249–3253
- Publication date:
- 2017-02-28
- Acceptance date:
- 2017-02-16
- DOI:
- EISSN:
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2041-6539
- ISSN:
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2041-6520
- Pubs id:
-
pubs:680397
- UUID:
-
uuid:7252901c-1fba-4520-ace1-7dcda651048e
- Local pid:
-
pubs:680397
- Source identifiers:
-
680397
- Deposit date:
-
2017-02-16
Terms of use
- Copyright holder:
- © The Royal Society of Chemistry 2017
- Copyright date:
- 2017
- Notes:
- © The Royal Society of Chemistry 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence, see: https://creativecommons.org/licenses/by/3.0/
- Licence:
- CC Attribution (CC BY)
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