Journal article icon

Journal article

A multidimensional diversity-oriented synthesis strategy for structurally diverse and complex macrocycles

Abstract:

Synthetic macrocycles are an attractive area in drug discovery. However, their use has been hindered by a lack of versatile platforms for the generation of structurally (and thus shape) diverse macrocycle libraries. Herein, we describe a new concept in library synthesis, termed multidimensional diversity-oriented synthesis, and its application towards macrocycles. This enabled the step-efficient generation of a library of 45 novel, structurally diverse, and highly-functionalized macrocycles b...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/anie.201605460

Authors


Trinity College, Cambridge More from this funder
AstraZeneca More from this funder
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
55
Issue:
37
Pages:
11139-11143
Publication date:
2016-08-03
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Pmid:
27484830
Source identifiers:
736828
Language:
English
Keywords:
Pubs id:
pubs:736828
UUID:
uuid:72347137-e78a-4664-a986-6ecd3c3f3600
Local pid:
pubs:736828
Deposit date:
2018-07-12

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP