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Journal article

Alpha-tropomyosin mutations in inherited cardiomyopathies.

Abstract:

The inherited cardiac diseases hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) can both be caused by missense mutations in the TPM1 gene which encodes the thin filament regulatory protein α-tropomyosin. Different mutations are responsible for either HCM or DCM, suggesting that distinct changes in tropomyosin structure and function can lead to the different diseases. Various biophysical and physiological approaches have been used to investigate the structure-function effects...

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Publication status:
Published

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Publisher copy:
10.1007/s10974-013-9358-5

Authors


Journal:
Journal of muscle research and cell motility
Volume:
34
Issue:
3-4
Pages:
285-294
Publication date:
2013-08-05
DOI:
EISSN:
1573-2657
ISSN:
0142-4319
URN:
uuid:7219e810-7aec-48d1-8398-7d945e90dffc
Source identifiers:
421094
Local pid:
pubs:421094

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