Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations.

Journal article

To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.

Authors: Fang, G; Kuiken, C; Weiser, B; Rowland-Jones, S; Plummer, F

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 190
• Issue: 4
• Pages: 697-701
• Publication date: 2004-08-01
• DOI: 10.1086/421504
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Prostitution; HLA Antigens; Kenya; Receptors, CCR2; Cohort Studies; Receptors, Chemokine; Occupational Diseases; Polymorphism, Genetic; Chemokine CCL2; Alleles; Molecular Sequence Data; RNA, Viral; Genotype; Humans; HIV-1; Female; HIV Infections; Adult