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The angiogenic process as a therapeutic target in cancer.

Abstract:

Angiogenesis has emerged as a critical process for tumour progression. Identifying key pathways involved in the regulation and promotion of angiogenesis has resulted in the development of numerous approaches targeting pro-angiogenic signalling pathways. The most prominent and characterised pro-angiogenic pathway is the vascular endothelial growth factor signalling pathway. This review will describe several inhibitors of angiogenesis currently in clinical trial and their various targets. Targe...

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Publisher copy:
10.1016/j.bcp.2011.02.016

Authors


Bridges, EM More by this author
Harris, AL More by this author
Journal:
Biochemical pharmacology
Volume:
81
Issue:
10
Pages:
1183-1191
Publication date:
2011-05-05
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
URN:
uuid:71ef5c3b-a271-4e5a-937f-f28a18c4e8ae
Source identifiers:
149761
Local pid:
pubs:149761

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