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Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network.

Abstract:

The Severe Malaria in African Children (SMAC) network was established to conduct mortality-based trials. Although falciparum malaria kills more than one million children each year, single centers cannot enroll enough patients to detect reductions of 20-30% in mortality rates. Our aim was to quantify and describe severe malaria across a variety of epidemiological settings so that we could design intervention studies with more precise sample size estimates. We used a standardized surveillance m...

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Publication status:
Published

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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
100
Issue:
7
Pages:
615-622
Publication date:
2006-07-05
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:71e20fb2-dfcf-4f9e-8ce6-7d84576e14c3
Source identifiers:
185700
Local pid:
pubs:185700

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