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iRhom2 is required for the secretion of mouse TNFα.

Abstract:

TNFα is a powerful inflammatory stimulus, central both to the control of infection, and as an agent of inflammatory disease. The most potent inducers of TNFα secretion signal through the Toll-like receptors, and we describe here a chemically-induced mutation that impairs this response in macrophages. A missense mutation was revealed in the gene encoding the inactive rhomboid protease iRhom2, which was not complemented by a null allele of the same gene. Neither the missense nor the null allele...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Tomisato, W More by this author
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Journal:
Blood
Volume:
119
Issue:
24
Pages:
5769-5771
Publication date:
2012-06-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:71ab5cd2-0e8c-4ca6-987d-6e8c1e679ede
Source identifiers:
418816
Local pid:
pubs:418816

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