Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Journal article

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC. © 2012 Nature America, Inc. All rights reserved.

Authors: Dunlop, MG; Dobbins, SE; Farrington, S; Jones, A; Palles, C

• Journal: Nature Genetics
• Volume: 44
• Issue: 7
• Pages: 770-776
• Publication date: 2012-07-01
• DOI: 10.1038/ng.2293
• EISSN: 1546-1718
• ISSN: 1061-4036