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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Abstract:

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings ...

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Publisher copy:
10.1038/ng.2293

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Journal:
Nature Genetics
Volume:
44
Issue:
7
Pages:
770-776
Publication date:
2012-07-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:71927d2a-79e4-4f50-9bd8-a63cf6452372
Source identifiers:
342125
Local pid:
pubs:342125

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