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Normalization of insulin responses to glucose by overnight infusion of glucagon-like peptide 1 (7-36) amide in patients with NIDDM.

Abstract:

Glucagon-like peptide 1 (GLP-1) is a natural enteric incretin hormone, which is a potent insulin secretogogue in vitro and in vivo in humans. Its effects on overnight glucose concentrations and the specific phases of insulin response to glucose and nonglucose secretogogues in subjects with NIDDM are not known. We compared the effects of overnight intravenous infusion of GLP-1 (7-36) amide with saline infusion, on overnight plasma concentrations of glucose, insulin, and glucagon in eight subje...

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Publication status:
Published

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Publisher copy:
10.2337/diab.45.11.1524

Authors


Rachman, J More by this author
Gribble, FM More by this author
Barrow, BA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Buchanan, KD More by this author
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Journal:
Diabetes
Volume:
45
Issue:
11
Pages:
1524-1530
Publication date:
1996-11-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:716fb2bf-d7d4-4bed-89f7-dd16c7cc700c
Source identifiers:
35985
Local pid:
pubs:35985

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