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Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways

Abstract:
STUDY QUESTION: Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships?
SUMMARY ANSWER: Our results confirm a significant but non-causal association of endometriosis with asthma implicating shared genetic susceptibility and biological pathways in the mechanisms of the disorders, and potentially, their co-occurrence.
WHAT IS KNOWN ALREADY: Some... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/humrep/deab254

Authors

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Sub department:
H5 HUMAN GENETICS WT CENTRE; HE NDWRH
Role:
Contributor
ORCID:
0000-0002-5169-8571
Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Sub department:
HE NDWRH; HE WOMEN’S & REPRODUCTIVE HEALTH; HE WOMEN'S & REPRODUCTIVE HEALTH
Role:
Contributor
ORCID:
0000-0002-0275-9905

More from this funder
Funder identifier:
https://ror.org/04txyc737

Publisher:
Oxford University Press
Journal:
Human Reproduction More from this journal
Volume:
37
Issue:
2
Pages:
366-383
Place of publication:
England
Publication date:
2021-12-16
Acceptance date:
2021-10-28
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
Pmid:
35472084

Language:
English
Keywords:
Pubs id:
1878529
UUID:
uuid_71317304-69ca-4efe-a6b5-37681278b240
Local pid:
pubs:1878529
Source identifiers:
W4213179251
Deposit date:
2025-11-28
ARK identifier:

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