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Half-life of exogenous growth hormone following suppression of endogenous growth hormone secretion with somatostatin in type I (insulin-dependent) diabetes mellitus.

Abstract:

OBJECTIVE: To estimate the half-life of growth hormone in young adult patients with type I (insulin-dependent) diabetes mellitus following bolus injection and prolonged exposure for the purpose of deconvolution analysis of plasma growth hormone profiles to determine growth hormone secretory rates. DESIGN: In the bolus study, an intravenous bolus injection of 100 mU of biosynthetic human growth hormone was given while endogenous growth hormone was suppressed by a continuous infusion of somatos...

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Publication status:
Published

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Authors


Mullis, PE More by this author
Matthews, DR More by this author
Hindmarsh, PC More by this author
Phillips, PE More by this author
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Journal:
Clinical endocrinology
Volume:
36
Issue:
3
Pages:
255-263
Publication date:
1992-03-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:711fd12f-3067-489c-acc6-006a384091dd
Source identifiers:
72854
Local pid:
pubs:72854

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