Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

Journal article

It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.

Authors: Novelli, MR; Williamson, J; Tomlinson, I; Elia, G; Hodgson, S

• Journal: Science (New York, N.Y.)
• Volume: 272
• Issue: 5265
• Pages: 1187-1190
• Publication date: 1996-05-01
• DOI: 10.1126/science.272.5265.1187
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Colon; DNA Probes; In Situ Hybridization; Karyotyping; Adult; Clone Cells; Mosaicism; Genotype; Ileum; Adenomatous Polyposis Coli; Phenotype; Y Chromosome; Humans; In Situ Hybridization, Fluorescence; Male; Intestinal Mucosa