Membrane-type matrix metalloproteinases: Their functions and regulations

Journal article

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, -MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (MT4- and MT6-MMPs). In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well. Further investigations of MT-MMPs are likely to reveal novel pathophysiological mechanisms and potential therapeutic strategies for different diseases in the future.

Authors: Itoh, Y

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Matrix Biology: Metalloproteinases in Extracellular Matrix Biology
• Volume: 44-46
• Pages: 207-223
• Publication date: 2015-03-17
• Acceptance date: 2015-03-11
• DOI: 10.1016/j.matbio.2015.03.004
• EISSN: 1569-1802
• ISSN: 0945-053X
• Pmid: 25794647
• Language: English
• Keywords: Humans; Animals; Neoplasms; Cell Membrane; Journal Article; Review; Matrix Metalloproteinases, Membrane-Associated; SBTMR; Arthritis; Research Support, Non-U.S. Gov't; Gene Expression Regulation, Enzymologic