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Membrane-type matrix metalloproteinases: Their functions and regulations

Abstract:

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, -MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (MT4- and MT6-MMPs). In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behavio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.matbio.2015.03.004

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0002-2128-2823
Publisher:
Elsevier Publisher's website
Journal:
Matrix Biology: Metalloproteinases in Extracellular Matrix Biology Journal website
Volume:
44-46
Pages:
207-223
Publication date:
2015-03-17
Acceptance date:
2015-03-11
DOI:
EISSN:
1569-1802
ISSN:
0945-053X
Pmid:
25794647
Source identifiers:
514711
Language:
English
Keywords:
Pubs id:
pubs:514711
UUID:
uuid:70d4bc31-8050-4799-b304-3f726b71ee70
Local pid:
pubs:514711
Deposit date:
2019-06-26

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