Journal article
Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment
- Abstract:
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Gene expression during development and differentiation is regulated in a cell- and stage-specific manner by complex networks of intergenic and intragenic cis-regulatory elements whose numbers and representation in the genome far exceed those of structural genes. Using chromosome conformation capture, it is now possible to analyze in detail the interaction between enhancers, silencers, boundary elements and promoters at individual loci, but these techniques are not readily scalable. Here we pr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 7.9MB, Terms of use)
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- Publisher copy:
- 10.1038/ng.2871
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Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Genetics More from this journal
- Volume:
- advance on
- Issue:
- 2
- Pages:
- 205-212
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:446584
- UUID:
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uuid:70c4e8bd-b9fb-40a2-a40c-4052d65a48f7
- Local pid:
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pubs:446584
- Source identifiers:
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446584
- Deposit date:
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2014-01-30
Terms of use
- Copyright holder:
- Hughes et al
- Copyright date:
- 2014
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature at: http://dx.doi.org/10.1038/ng.2871
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