Journal article : Review
Bacterial defences: mechanisms, evolution and antimicrobial resistance
- Abstract:
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Throughout their evolutionary history, bacteria have faced diverse threats from other microorganisms, including competing bacteria, bacteriophages and predators. In response to these threats, they have evolved sophisticated defence mechanisms that today also protect bacteria against antibiotics and other therapies. In this Review, we explore the protective strategies of bacteria, including the mechanisms, evolution and clinical implications of these ancient defences. We also review the countermeasures that attackers have evolved to overcome bacterial defences. We argue that understanding how bacteria defend themselves in nature is important for the development of new therapies and for minimizing resistance evolution.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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-
(Preview, Accepted manuscript, pdf, 771.0KB, Terms of use)
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- Publisher copy:
- 10.1038/s41579-023-00877-3
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Reviews Microbiology More from this journal
- Volume:
- 21
- Issue:
- 8
- Pages:
- 519–534
- Publication date:
- 2023-04-24
- Acceptance date:
- 2023-02-27
- DOI:
- EISSN:
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1740-1534
- ISSN:
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1740-1526
- Pmid:
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37095190
- Language:
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English
- Keywords:
- Subjects:
- Subtype:
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Review
- Pubs id:
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1339016
- Local pid:
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pubs:1339016
- Deposit date:
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2023-05-25
- ARK identifier:
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2023
- Rights statement:
- © Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author selfarchiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Springer Nature at https://dx.doi.org/10.1038/s41579-023-00877-3
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