Protons and Ca2+: ionic allies in tumor progression?

Journal article

Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca(2+) influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is characterized by extracellular acidosis that promotes the pathological phenotype. The pathway(s) by which extracellular protons achieve this remain unclear. Here, a role for proton-sensing ion channels and GPCRs as mediators of the effects of extracellular protons in cancer cells is discussed.

Authors: Glitsch, M

• Publication status: Published
• Journal: Physiology (Bethesda, Md.)
• Volume: 26
• Issue: 4
• Pages: 252-265
• Publication date: 2011-08-01
• DOI: 10.1152/physiol.00005.2011
• EISSN: 1548-9221
• ISSN: 1548-9213
• Language: English
• Keywords: Disease Progression; Protons; Neoplasms; Humans; Ion Channels; Hydrogen; Animals; Calcium Signaling; Calcium; Receptors, G-Protein-Coupled