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Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity.

Abstract:

Patients with cobalt chrome (CoCr) metal-on-metal (MOM) implants may be exposed to a wide size range of metallic nanoparticles as a result of wear. In this study we have characterised the biological responses of human fibroblasts to two types of synthetically derived CoCr particles [(a) from a tribometer (30 nm) and (b) thermal plasma technology (20, 35, and 80 nm)] in vitro, testing their dependence on nanoparticle size or the generation of oxygen free radicals, or both. Metal ions were rele...

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Publication status:
Published

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Authors


Raghunathan, VK More by this author
Hawkins, S More by this author
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Journal:
Biomaterials
Volume:
34
Issue:
14
Pages:
3559-3570
Publication date:
2013-05-05
DOI:
EISSN:
1878-5905
ISSN:
0142-9612
URN:
uuid:709e78b1-6823-4a13-9918-ecf18c84bc8d
Source identifiers:
387094
Local pid:
pubs:387094

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