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Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases

Abstract:

Post-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases, and occurs in prokaryotes and eukaryotes. OGFOD1 catalyzes trans-3 prolyl hydroxylation at Pro62 of the small ribosomal subunit protein uS12 (RPS23) and is conserved from yeasts to humans. We describe crystal structures of the human uS12 prolyl 3-hydroxylase (OGFOD1) and its homolog from Saccharomyces cerevisiae (Tpa1p): OGFOD1 in complex with the broad-spectrum 2OG o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.str.2015.01.014

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Department:
Physiology and Anatomy
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Department:
Chemistry Research Laboratory
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Department:
Chemistry Research Laboratory
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Department:
Chemistry Research Laboratory
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Department:
Chemistry Research Laboratory
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Funding agency for:
Project
Publisher:
Elsevier Publisher's website
Journal:
Structure
Volume:
23
Issue:
4
Pages:
639-652
Publication date:
2015-02-26
Acceptance date:
2015-01-21
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English

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