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Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

Abstract:

Heterozygous HNF1A mutations cause pancreatic-islet beta-cell dysfunction and monogenic diabetes (MODY3). Hnf1alpha is known to regulate numerous hepatic genes, yet knowledge of its function in pancreatic islets is more limited. We now show that Hnf1a deficiency in mice leads to highly tissue-specific changes in the expression of genes involved in key functions of both islets and liver. To gain insights into the mechanisms of tissue-specific Hnf1alpha regulation, we integrated expression stud...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.01389-08

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Journal:
Molecular and cellular biology
Volume:
29
Issue:
11
Pages:
2945-2959
Publication date:
2009-06-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:701b0f04-b15e-4423-8a67-52301bf38cd2
Source identifiers:
18066
Local pid:
pubs:18066

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