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Journal article

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.

Abstract:

During meiosis, two rounds of chromosome segregation after a single round of DNA replication produce haploid gametes from diploid precursors. At meiosis I, maternal and paternal kinetochores are pulled toward opposite poles, and chiasmata holding bivalent chromosomes together are resolved by cleavage of cohesin's alpha-kleisin subunit (Rec8) along chromosome arms. This creates dyad chromosomes containing a pair of chromatids joined solely by cohesin at centromeres that had resisted cleavage. ...

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Publication status:
Published

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Authors


Bogdanova, A More by this author
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Journal:
Developmental cell
Volume:
18
Issue:
3
Pages:
397-409
Publication date:
2010-03-05
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
URN:
uuid:70175f45-acbf-4abb-90c4-3f3d97df96a1
Source identifiers:
98367
Local pid:
pubs:98367

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