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Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach.

Abstract:

Small heat-shock proteins (sHSPs) are molecular chaperones that prevent irreversible aggregation through binding nonnative target proteins. Due to their heterogeneity, these sHSP:target complexes remain poorly understood. We present a nanoelectrospray mass spectrometry analysis algorithm for estimating the distribution of stoichiometries comprising a polydisperse ensemble of oligomers. We thus elucidate the organization of complexes formed between sHSPs and different target proteins. We find ...

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Publication status:
Published

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Authors


Stengel, F More by this author
Baldwin, AJ More by this author
Hilton, GR More by this author
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Journal:
Chemistry and biology
Volume:
19
Issue:
5
Pages:
599-607
Publication date:
2012-05-05
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
URN:
uuid:70135646-cbeb-4748-99c4-15fbee5e2e98
Source identifiers:
334755
Local pid:
pubs:334755

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