Journal article icon

Journal article

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.

Abstract:

BACKGROUND: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolutionary pathways, we investigated AA co-variation in Gag sequences obtained from 449 South African individuals chronically infected with HIV-1 subtype C. METHODOLOGY/PRINCIPAL FINDINGS: Individuals...

Expand abstract

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0012463

Authors


Rolland, M More by this author
Carlson, JM More by this author
Manocheewa, S More by this author
Lanxon-Cookson, E More by this author
Expand authors...
Journal:
PloS one
Volume:
5
Issue:
9
Pages:
e12489
Publication date:
2010
DOI:
EISSN:
1932-6203
URN:
uuid:6ff05a03-00b5-4b29-8ee6-1e0e2ed61df2
Source identifiers:
191243
Local pid:
pubs:191243

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP