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Anesthesia-induced suppression of human dorsal anterior insula responsivity at loss of volitional behavioral response

Abstract:

It has been postulated that a small cortical region could be responsible for the loss of behavioral responsiveness (LOBR) during general anesthesia. The authors hypothesize that any brain region demonstrating reduced activation to multisensory external stimuli around LOBR represents a key cortical gate underlying this transition. Furthermore, the authors hypothesize that this localized suppression is associated with breakdown in frontoparietal communication.During both simultaneous electroenc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Department:
Oxford, Societies Other & Companies, St Cross College
Seretny, M More by this author
Ní Mhuircheartaigh, R More by this author
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Department:
Linacre College
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Wellcome Trust More from this funder
National Institute for Academic Anaesthesia More from this funder
International Anesthesia Research Society More from this funder
Scottish Society of Anaesthetists More from this funder
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
Anesthesiology Journal website
Volume:
124
Issue:
4
Pages:
766-778
Publication date:
2016-04-05
DOI:
EISSN:
1528-1175
ISSN:
0003-3022
Pubs id:
pubs:597872
URN:
uri:6fd68304-2add-4ab8-b1df-aa3ea6bd5330
UUID:
uuid:6fd68304-2add-4ab8-b1df-aa3ea6bd5330
Local pid:
pubs:597872

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