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LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package

Abstract:

Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 knockdown or LIMK1 inhibition. Here we present a target enabling package for the t...

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Version:
3

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Role:
Principal Investigator, Creator

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Role:
Researcher
Department:
Organic Chemistry
Role:
Researcher
Department:
Structural Genomics
Role:
Researcher
Department:
Structural Genomics
Role:
Researcher
Department:
Structural Genomics
Role:
Researcher
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Grant:
106169/ZZ14/Z
Funding agency for:
Project
Publisher:
University of Oxford
Publication date:
2018

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