Dataset
LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
- Version:
- 3
Actions
Authors/Creators
Contributors
+ Mathea, S
Role:
Researcher
+ Salah, E
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Researcher
+ Knapp, S
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Beltrami, A
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Chaikuad, A
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Expand contributors...
Funding
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Version number:
- 3
Item Description
- Keywords:
- Subjects:
- Documentation:
-
A description of the materials and methods is included within the TEP datasheet. Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 k... Expand documentation
- UUID:
-
uuid:6fc2d646-a99d-477a-bdc0-187c6047ebb0
- Deposit date:
- 2018-05-08
Related Items
Terms of use
- Copyright date:
- 2018
- Notes:
- This document represents version 3 of the TEP datasheet and includes all updates on the project as of April 2018. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
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