Dataset
LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
- Abstract:
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Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 knockdown or LIMK1 inhibition. Here we present a target enabling package for the t...
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- Version:
- 3
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Authors/Creators
Contributors
+ Sebastian Mathea
Role:
Researcher
+ Eidarus Salah
Department:
Organic Chemistry
Role:
Researcher
+ Stefan Knapp
Department:
Structural Genomics
Role:
Researcher
+ Alessandra Beltrami
Department:
Structural Genomics
Role:
Researcher
+ Apirat Chaikuad
Department:
Structural Genomics
Role:
Researcher
Expand contributors...
Funding
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2018
Item Description
- Keywords:
- Subjects:
- Format:
- Digital
- Documentation:
- A description of the materials and methods is included within the TEP datasheet.
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- Copyright date:
- 2018
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