- Abstract:
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Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 knockdown or LIMK1 inhibition. Here we present a target enabling package for the t...
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- Role:
- Researcher
- Department:
- Organic Chemistry
- Role:
- Researcher
- Department:
- Structural Genomics
- Role:
- Researcher
- Department:
- Structural Genomics
- Role:
- Researcher
- Department:
- Structural Genomics
- Role:
- Researcher
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Keywords:
- Subjects:
- Format:
- Digital
- Documentation:
- A description of the materials and methods is included within the TEP datasheet.
- Copyright date:
- 2018
Dataset
LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
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Authors
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+ Sebastian Mathea
+ Eidarus Salah
+ Stefan Knapp
+ Alessandra Beltrami
+ Apirat Chaikuad
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