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LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package

Version:
3

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Role:
Principal Investigator (PI), Creator

Contributors

Role:
Researcher
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
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Publisher:
University of Oxford
Publication date:
2018
Version number:
3
Keywords:
Subjects:
Documentation:
A description of the materials and methods is included within the TEP datasheet. Loss of the translational repressor FMRP in fragile X syndrome causes upregulation of the type II BMP receptor BMPR2 and its non-canonical signalling via the kinase LIMK1. LIMK1 performs inhibitory phosphorylation on cofilin proteins blocking their actin-severing activity. Excessive BMPR2-LIMK1 activation was associated with dendritic spine and behavioural defects in animal models that could be rescued by BMPR2 k... Expand documentation
UUID:
uuid:6fc2d646-a99d-477a-bdc0-187c6047ebb0
Deposit date:
2018-05-08

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