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Structure of human complement C8, a precursor to membrane attack.

Abstract:

Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation. High-resolution structures of C8 subunits have provided some insight into the function of the C8 heterotrimer; however, there is no structural information describing how the intersubunit organization facilitates MAC assembly. We have determined the structure of C8 by electron micros...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2010.10.031

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Journal of molecular biology
Volume:
405
Issue:
2
Pages:
325-330
Publication date:
2011-01-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:6fa51340-3c30-4a66-bf29-47e53fdfc5ea
Source identifiers:
94158
Local pid:
pubs:94158

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