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Probing the structural basis of RecQ helicase function

Abstract:

RecQ helicases are a ubiquitous family of DNA unwinding enzymes required to preserve genome integrity, thus preventing premature aging and cancer formation. The five human representatives of this family play non-redundant roles in the suppression of genome instability using a combination of enzymatic activities that specifically characterize each member of the family. These enzymes are in fact not only able to catalyze the transient opening of DNA duplexes, as any other conventional helicase,...

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Authors


Vindigni, Alessandro More by this author
Marino, Francesca More by this author
Gileadi, Opher More by this author
Journal:
Biophysical Chemistry
Volume:
149
Issue:
3
Pages:
67-77
Publication date:
2010
ISSN:
1873-4200
URN:
uuid:6f8d4c92-aa1d-4802-af56-cb73c1c733ee
Local pid:
SGC:20392558

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