Journal article icon

Journal article

Advances in hypoxia-inducible factor biology

Abstract:

Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis and metabolic activation. Beyond this, HIF influences many other processes. Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation and histone acetylation, which modulate hypoxia-responsive gene expression in cells. Hypoxia profoundly affects expression of many noncoding RN...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1016/j.cmet.2017.10.005

Authors


More by this author
Role:
Author
ORCID:
0000-0003-0401-6619
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; Weatherall Insti. of Molecular Medicine
Oxford college:
St Hughs College
Role:
Author
Deanship of Scientific Research More from this funder
More from this funder
Grant:
Research Endowment Fund (WAQF) (H.C.)
Jeddah the Ministry of Education for Saudi Arabia More from this funder
More from this funder
Grant:
C602/A18974 to A.L.H.
Publisher:
Cell Press Publisher's website
Journal:
Cell Metabolism Journal website
Volume:
27
Issue:
2
Pages:
281-298
Publication date:
2017-11-09
Acceptance date:
2017-10-12
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
Pubs id:
pubs:796971
URN:
uri:6f8a28d0-6046-4af8-a4f6-ea745ae68046
UUID:
uuid:6f8a28d0-6046-4af8-a4f6-ea745ae68046
Local pid:
pubs:796971
Paper number:
2

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP