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The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons.

Abstract:

The protein alpha-synuclein is central to the pathophysiology of Parkinson's disease (PD) but its role in the development of neurodegeneration remains unclear. alpha-Synuclein-knockout mice develop without gross abnormality and are resistant to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a mitochondrial inhibitor widely used to model parkinsonism. Here we show that differentiated human dopaminergic neuron-like cells also have increased resistance to 1-methyl-4-phenylpyridine (MPP+), ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
The European journal of neuroscience
Volume:
28
Issue:
12
Pages:
2459-2473
Publication date:
2008-12-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:6f81f251-ec6f-4d99-8096-22d36183eaec
Source identifiers:
105285
Local pid:
pubs:105285

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