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hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer.

Abstract:

The pattern of hMLHI and hMSH2 mutations was assessed to identify the genetic correlation between hereditary gastric and colorectal cancers. Four disease groups and their healthy family members were assembled according to the presentation of gastric cancer: FG, familial clustering of gastric cancer (n = 32); CG, family with one or more colorectal and gastric cancers in first-degree relatives (n = 22); HS, seven HNPCC families corresponding to the Amsterdam criteria (AMS+) and 12 suspected HNP...

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Publication status:
Published

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Journal:
Cancer detection and prevention
Volume:
25
Issue:
6
Pages:
503-510
Publication date:
2001
EISSN:
1525-1500
ISSN:
0361-090X
URN:
uuid:6f64d2d1-b866-47b5-b546-7e1368a87b06
Source identifiers:
178030
Local pid:
pubs:178030

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