Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region.

Journal article

Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region. Previous LOH and CGH studies have refined this region to 7q22.3-q31, although the target gene has not been identified. Here, we have used tiling-path resolution microarray CGH to further refine the region and to identify homozygous deletions in fibroids. Furthermore, we have screened all manually annotated genes in the reg...

Expand abstract

Authors: Vanharanta, S; Wortham, N; Langford, C; El-Bahrawy, M; van der Spuy, Z

• Journal: Genes, chromosomes and cancer
• Volume: 46
• Issue: 5
• Pages: 451-458
• Publication date: 2007-05-01
• DOI: 10.1002/gcc.20427
• EISSN: 1098-2264
• ISSN: 1045-2257
• Language: English
• Keywords: DNA Damage; Oligonucleotide Array Sequence Analysis; Chromosomes, Human, Pair 7; Sequence Deletion; Uterine Neoplasms; Nucleic Acid Hybridization; Leiomyoma; DNA Mutational Analysis; Hysterectomy; Humans; Female; DNA, Neoplasm; Neoplasm Proteins; Chromosome Mapping