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Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply.

Abstract:

OBJECTIVES: Cellular expression of non-classical forms of human leukocyte antigen (HLA)-B27 (NC-B27) may be involved in spondyloarthritis (SpA) pathogenesis. We used a novel B27-specific monoclonal antibody, HD6, to ask if B27 transgenic (TG) rat splenocytes express these NC-B27 molecules. We also investigated whether B27-binding peptides could affect the expression and functional immune recognition of HD6-reactive B27 molecules. METHODS: Splenocytes from B27-TG, B7-TG and non-transgenic rats...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, Experimental Medicine Division
Role:
Author
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Journal:
Annals of the rheumatic diseases
Volume:
73
Issue:
4
Pages:
763-770
Publication date:
2014-04-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:6f360593-5d4f-4289-8cee-597612aff3b3
Source identifiers:
401838
Local pid:
pubs:401838

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