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Comprehensive identification of RNA-binding domains in human cells

Abstract:

Mammalian cells harbor more than a thousand RNAbinding proteins (RBPs), with half of these employing unknown modes of RNA binding. We developed RBDmap to determine the RNA-binding sites of native RBPs on a proteome-wide scale. We identified 1,174 binding sites within 529 HeLa cell RBPs, discovering numerous RNA-binding domains (RBDs). Catalytic centers or protein-protein interaction domains are in close relationship with RNA-binding sites, invoking possible effector roles of RNA in the contro...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.molcel.2016.06.029

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Department:
Oxford, MSD, Biochemistry
Fischer, B More by this author
Alleaume, A-M More by this author
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Funding agency for:
Castello Palomares, A
German Ministry for Science and Education More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Publication date:
2016-07-05
DOI:
ISSN:
1097-4164
Pubs id:
pubs:629323
URN:
uri:6f25d6fc-de12-41e9-acaa-88bc17f96c4f
UUID:
6f25d6fc-de12-41e9-acaa-88bc17f96c4f
Local pid:
pubs:629323

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