Journal article
Comprehensive identification of RNA-binding domains in human cells
- Abstract:
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Mammalian cells harbor more than a thousand RNAbinding proteins (RBPs), with half of these employing unknown modes of RNA binding. We developed RBDmap to determine the RNA-binding sites of native RBPs on a proteome-wide scale. We identified 1,174 binding sites within 529 HeLa cell RBPs, discovering numerous RNA-binding domains (RBDs). Catalytic centers or protein-protein interaction domains are in close relationship with RNA-binding sites, invoking possible effector roles of RNA in the contro...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 27.3MB)
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- Publisher copy:
- 10.1016/j.molcel.2016.06.029
Authors
Funding
+ Medical Research Council
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Funding agency for:
Castello Palomares, A
Grant:
MR/L019434/1
German Ministry for Science and Education
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Molecular Cell Journal website
- Publication date:
- 2016-07-01
- Acceptance date:
- 2016-06-20
- DOI:
- ISSN:
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1097-4164
Item Description
- Keywords:
- Pubs id:
-
pubs:629323
- UUID:
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uuid:6f25d6fc-de12-41e9-acaa-88bc17f96c4f
- Local pid:
- pubs:629323
- Source identifiers:
-
629323
- Deposit date:
- 2016-08-05
Terms of use
- Copyright holder:
- Castello Palomares et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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