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Comprehensive identification of RNA-binding domains in human cells

Abstract:

Mammalian cells harbor more than a thousand RNAbinding proteins (RBPs), with half of these employing unknown modes of RNA binding. We developed RBDmap to determine the RNA-binding sites of native RBPs on a proteome-wide scale. We identified 1,174 binding sites within 529 HeLa cell RBPs, discovering numerous RNA-binding domains (RBDs). Catalytic centers or protein-protein interaction domains are in close relationship with RNA-binding sites, invoking possible effector roles of RNA in the contro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Name:
Medical Research Council
Funding agency for:
Castello Palomares, A
Grant:
MR/L019434/1
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Name:
European Molecular Biology Organization
Grant:
LTF1006-2013
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Name:
European Research Council
Grant:
ERC-2011-ADG_20110310
More from this funder
Name:
German Ministry for Science and Education
Publisher:
Cell Press
Journal:
Molecular Cell More from this journal
Publication date:
2016-07-01
Acceptance date:
2016-06-20
DOI:
ISSN:
1097-4164
Keywords:
Pubs id:
pubs:629323
UUID:
uuid:6f25d6fc-de12-41e9-acaa-88bc17f96c4f
Local pid:
pubs:629323
Source identifiers:
629323
Deposit date:
2016-08-05

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