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The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.

Abstract:

The selective non-competitive NMDA receptor antagonist, MK-801, potently blocked convulsions induced in the mouse by N-methyl-DL-aspartic acid (NMDLA) with an i.v. ED50 dose of 0.2 mg/kg. Similar doses of MK-801 were also effective in blocking seizures induced by pentylenetetrazol (PTZ), electroshock and by sound in audiogenic seizure-prone animals. Other less selective non-competitive NMDA receptor antagonists including phencyclidine (PCP), thienylcyclohexylpiperidine (TCP), (+)-N-allylnorme...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
European journal of pharmacology More from this journal
Volume:
167
Issue:
1
Pages:
127-135
Publication date:
1989-08-01
DOI:
EISSN:
1879-0712
ISSN:
0014-2999

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