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Journal article

Synchronised infection identifies early rate‐limiting steps in the hepatitis B virus life cycle

Abstract:

Hepatitis B virus (HBV) is an enveloped DNA virus that contains a partially double‐stranded relaxed circular (rc) DNA. Upon infection, rcDNA is delivered to the nucleus where it is repaired to covalently closed circular (ccc) DNA that serves as the transcription template for all viral RNAs. Our understanding of HBV particle entry dynamics and host pathways regulating intracellular virus trafficking and cccDNA formation is limited. The discovery of sodium taurocholate co‐transporting peptide (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/cmi.13250

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Cellular Microbiology Journal website
Volume:
22
Issue:
12
Article number:
e13250
Publication date:
2020-09-28
Acceptance date:
2020-07-27
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
Language:
English
Keywords:
Pubs id:
1123128
Local pid:
pubs:1123128
Deposit date:
2020-08-01

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