Journal article icon

Journal article

Effect of adverse events on non-adherence and study non-completion in malaria chemoprevention during pregnancy trial: A nested case control study

Abstract:

Background: In drug trials, adverse events (AEs) burden can induce treatment non-adherence or discontinuation. The non-adherence and discontinuation induce selection bias, affecting drug safety interpretation. Nested case-control (NCC) study can efficiently quantify the impact of the AEs, although choice of sampling approach is challenging. We investigated whether NCC study with incidence density sampling is more efficient than NCC with path sampling under conditional...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0262797

Authors


More by this author
Role:
Author
ORCID:
0000-0002-3159-8207
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-5036-6583
More by this author
Role:
Author
ORCID:
0000-0003-3029-9579
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
17
Issue:
1
Article number:
e0262797
Publication date:
2022-01-19
Acceptance date:
2021-10-18
DOI:
EISSN:
1932-6203
Pmid:
35045119

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP