New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Journal article

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insuli...

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Authors: Dupuis, J; Langenberg, C; Prokopenko, I; Saxena, R; Soranzo, N

• Publication status: Published
• Journal: Nature genetics
• Volume: 42
• Issue: 2
• Pages: 105-116
• Publication date: 2010-02-01
• DOI: 10.1038/ng.520
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Adolescent; Anders Hamsten on behalf of Procardis Consortium; MAGIC investigators; DNA Copy Number Variations; Polymorphism, Single Nucleotide; Humans; Quantitative Trait, Heritable; Homeostasis; Diabetes Mellitus, Type 2; Databases, Genetic; GIANT Consortium; Genetic Predisposition to Disease; Reproducibility of Results; Meta-Analysis as Topic; Fasting; Genetic Loci; Blood Glucose; Genome-Wide Association Study; Adult; Global BPgen Consortium; Alleles; Gene Expression Regulation; Child; Quantitative Trait Loci; DIAGRAM Consortium