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Meta‐analysis and Mendelian randomization: A review

Abstract:

Mendelian randomization (MR) uses genetic variants as instrumental variables to infer whether a risk factor causally affects a health outcome. Meta‐analysis has been used historically in MR to combine results from separate epidemiological studies, with each study using a small but select group of genetic variants. In recent years, it has been used to combine genome‐wide association study (GWAS) summary data for large numbers of genetic variants. Heterogeneity among the causal estimates obtain...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/jrsm.1346

Authors


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Role:
Author
ORCID:
0000-0003-2628-3304
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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Publisher:
Wiley Publisher's website
Journal:
Research Synthesis Methods Journal website
Volume:
10
Issue:
4
Pages:
486-496
Publication date:
2019-03-12
Acceptance date:
2019-02-11
DOI:
EISSN:
1759-2887
ISSN:
1759-2879
Pmid:
30861319
Language:
English
Keywords:
Pubs id:
pubs:983986
UUID:
uuid:6f05ce17-1a02-4ce7-8ed1-bb365ab2dd76
Local pid:
pubs:983986
Source identifiers:
983986
Deposit date:
2019-03-28

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