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Evolution of drug-resistance genes in Plasmodium falciparum in an area of seasonal malaria transmission in Eastern Sudan.

Abstract:

We investigated the evolution of drug-resistant Plasmodium falciparum in a village in eastern Sudan. The frequencies of alleles of 4 genes thought to be determinants of drug resistance were monitored from 1990 through 2001. Changes in frequencies of drug-resistance genes between wet and dry seasons were monitored from 1998 through 2000. Parasites were also typed for 3 putatively neutral microsatellite loci. No significant variation in frequencies was observed for the microsatellite loci over ...

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Publication status:
Published

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Publisher copy:
10.1086/382509

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Journal of infectious diseases More from this journal
Volume:
189
Issue:
7
Pages:
1239-1244
Publication date:
2004-04-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899

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