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Journal article

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.

Abstract:

Intracellular responses to hypoxia are coordinated by the von Hippel-Lindau--hypoxia-inducible factor (VHL-HIF) transcriptional system. This study investigated the potential role of the VHL-HIF pathway in human systems-level physiology. Patients diagnosed with Chuvash polycythaemia, a rare disorder in which VHL signalling is specifically impaired, were studied during acute hypoxia and hypercapnia. Subjects breathed through a mouthpiece and ventilation was measured while pulmonary vascular ton...

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Publication status:
Published

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Publisher copy:
10.1007/978-0-387-73693-8_9

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Journal:
Advances in experimental medicine and biology
Volume:
605
Pages:
51-56
Publication date:
2008-01-01
DOI:
ISSN:
0065-2598
Source identifiers:
24663

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